Nancy Shepherd

Nancy is one of the four sisters of Derek Shepherd. Nancy lives in Connecticut and is a doctor in Obstetrics and Gynaecology.

Personal Life
When Meredith is annoyed that Derek isn't visiting, she goes to Derek's trailer and finds him fresh from the shower, with a woman on his bed. Meredith assumes Derek is cheating on her but it was just his sister Nancy. Meredith leaves before Derek can explain.

She came to Seattle to check up on him sice he's skipped the last few family holidays. She dislikes Meredith and repeatedly called her the slutty intern and, much to Derek's dismay, warmly embraces Mark and Addison.

She continues to hint to Derek to forgive Addison for her one-night stand with Mark, eventually Derek breaks and tells her that they carried on with their relationship for two months after he left. She then accepts this and goes home happily, accepting his decision. However before she goes, she gives him some advice. Nancy advises him that maybe he needs a little time alone, to sort things out. To commit to himself, rather than run circles around all the women in his life and Derek subsequently tells Meredith he does need a little time to himself, and she agrees.

Romantic Life
Nancy is presumably married and has children, which would form part of Derek's nine nieces and five nephews. It is also probable that she slept with Mark Sloan, as she made the comment that "sleeping with him was like a right of passage."

Career
Nancy is an OB/GYN.

While Nancy was in Seattle visiting Derek, she admits she left one of her pregnant patients in Connecticut, who is 35 weeks pregnant with twins, to see Derek and find out what was going on.

Nancy also wanted to see a special case at the hospital while she was there, Addison had a pregnant patient (Noel Levat) with uterus duplex bicollis (two uteruses) who later went into labour. Nancy scrubbed in and observed Addison and O'Malley deliver one of the two babies.