These Ties That Bind

"It's intense, what happens in the O.R. when lives are on the line. And you're poking at brains like they're silly putty. You form a bond with the surgeons right next to you. An unbreakable, indescribable bond. It's intimate, being tied together like that. Whether you like it or not, whether you like them or not, you become family. The ties that binds us are sometimes impossible to explain. They connect us even after it seems like the ties should be broken. Some bonds defy distance and time and logic; Because some ties are simply... meant to be."

- Meredith Grey

 is the eighth episode of the fifth season and the 86th overall episode of Grey's Anatomy.

Short Summary
An old friend of Meredith by the name of Sadie appears and causes some tension with Cristina. Bailey attempts to woo a cardiothorasic surgeon Virginia Dixon, Callie breaks down crying. Izzie confides in a patient about Denny and Cristina become suspicious about some of the interns.

Full Summary
Episode in detail.

Main Cast

 * Ellen Pompeo as Dr. Meredith Grey
 * Sandra Oh as Dr. Cristina Yang
 * Katherine Heigl as Dr. Izzie Stevens
 * Justin Chambers as Dr. Alex Karev
 * T.R. Knight as Dr. George O'Malley
 * Chandra Wilson as Dr. Miranda Bailey
 * James Pickens, Jr. as Dr. Richard Webber
 * Sara Ramírez as Dr. Callie Torres
 * Eric Dane as Dr. Mark Sloan
 * Chyler Leigh as Dr. Lexie Grey
 * Patrick Dempsey as Dr. Derek Shepherd

Special Guest Star

 * Jeffrey Dean Morgan as Denny Duquette

Guest Stars

 * Kevin McKidd as Dr. Owen Hunt
 * Melissa George as Dr. Sadie Harris
 * August Schellenberg as Clay Bedonie
 * Ed Lauter as Timothy Miller
 * Brandon Scott as Dr. Ryan Spalding
 * Mary McDonnell as Dr. Virginia Dixon

Co-Starring

 * Gloria Garayua as Intern Graciella
 * Mark Saul as Intern Steve
 * Molly Kidder as Intern Megan
 * Winston Story as Intern Leo
 * Joseph Williamson as Intern Pierce
 * Nicole Cummins as Jill the Paramedic

Uncredited

 * Matt J. Doyle as Bartender

Notes and Trivia
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 * This episode's title originated from the song , originally sung by RJ Cowdery.
 * This episode scored 15.59 million viewers.

Quotes

 * Izzie: I said goodbye. I burned the sweater!
 * Denny: Yeah, thanks for that, by the way. I loved that sweater. You made me that sweater. Izzie... stop freaking out.
 * Izzie: You're not real. You're not real.
 * Denny: Hey, I told you.
 * Izzie: You're not real! You're not real! You're not real!
 * Denny: Look at me. Touch me. (Izzie touches Denny's chest) See? Told you I was real.