Grey's Anatomy Universe Wiki

Fresh starts thanks to the calendar they happen every year- just set your watch to January, our reward for surviving the holiday season is a new year. Bringing on the great tradition of new years resolutions, put your past behind you and start over. It’s hard to resist the chance of a new beginning, a chance to put the problems of last year to bed. Who gets to determine when the old ends and the new begins? It’s not a day on a calendar, not a birthday, it’s not a new year, it’s an event— big or small, something that changes us, ideally it gives us hope, a new way of living and looking at the world, letting go of old habits, old memories. What's important is that we never stop believing we can have a new beginning, but it's also important to remember that amid all the crap are a few things really worth holding on to.

Begin the Begin is the thirteenth episode and mid-season premiere of the second season and the 22nd overall episode of Grey's Anatomy.

Short Summary[]

The Chief enforces the 80 hour work limit with an iron fist so Meredith has free-time, and so does Cristina, but she chooses to go to Twin Falls, Idaho with Bailey for a heart retrieval while the Chief asks Derek for a favor regarding Ellis Grey. George has a teenager who is actually different while Alex treats a man who has a bezoar and Izzie works on Denny Duquette.

Full Summary[]

Episode in detail.


Main Cast[]

Guest Stars[]




Medical Notes[]

Ellis Grey[]

  • Diagnosis:
    • Alzheimer's disease
  • Treatment:
    • Residential care

Ellis was shown at Roseridge Home for Extended Care. Derek came to visit her to see if she was eligible for a trial.

Burke's Patient[]

  • Diagnosis:
    • Mesothelioma
  • Treatment:
    • Surgery

Burke and Cristina were seen preparing to operate together on a patient with mesothelioma.

Denny Duquette, Jr.[]

  • Diagnosis:
    • Viral cardiomyopathy
  • Treatment:

Denny, 36, was told to come into the hospital when a heart became available for him, which he needed due to cardiomyopathy. However, the donor showed signs of coronary artery disease, so the heart was not suitable for transplant and he was sent home.

Rebecca Singleton[]

  • Diagnosis:
    • Elevated hormone levels
    • Tumor
  • Treatment:
    • Tumor resection
    • Oral medication

Bex, 14, was in the hospital for a biopsy on an enlargement of a pelvic lymph node. Bex was found to have elevated hormone levels which were caused by the consumption of birth control pills, but that could be controlled by oral medication. The ultrasound showed a tumor, which was compressing what they believed to be an ovary. However, further testing identified it as a testes, meaning Bex is intersex. The tumor was benign, but because of their condition, they recommended therapy for the family. Bex's parents asked Addison to remove the testicle, but she refused to do so without Bex's consent.

Malar Pascowitz[]

  • Diagnosis:
    • Bezoar
    • Mercury poisoning
  • Treatment:
    • Laxatives
    • Surgery
    • British anti-Lewisite

Malar was in the hospital to be treated for abdominal pain, caused by a bezoar. He had eaten a novel he'd written. Before his surgery, he was sweating profusely and babbling incoherently. The bezoar was removed successfully, but was diagnosed with mercury poisoning.

Heart Donor[]

  • Diagnosis:
    • Coronary artery disease
  • Doctors:
  • Treatment:

While attempting to retrieve a heart for Denny Duquette, Bailey saw signs of coronary artery disease, so the heart was deemed too damaged to be transplanted.


Song Performer Scene
"Hide Another Mistake" The 88
  • Izzie hides from Doc in the bathroom. She lets George in.
  • Meredith plays with Doc happily, but he growls at the others.
  • Derek brings a fish into the trailer, where Addison is frustrated over living there.
"One of These Days" Kraak and Smaak
  • Meredith tells Derek about Doc.
  • They claim to be over each other.
  • The elevator opens to reveal Addison.
  • Addison and Derek talk about Addison's passive-aggression.
"Ride" Cary Brothers
  • Bex's parents don't want to tell her she's intersex.
  • They also want Addison to remove her male sex organs.
  • Addison refuses and George says Bex will learn the truth eventually.
  • Meredith visits Ellis, who is already visiting with Derek.
"Break Your Momma's Back" Slow Runner
  • Meredith asks Derek about the trial for her mother.
  • Izzie walks Denny to the hospital door and says goodbye.
  • George cuts Bex's hair. Bex's mom comes in and takes over.
  • Addison comes home to find Derek cooking the trout outside.
  • He says she just has to wait it out with Meredith.
  • Cristina tells Burke that she was going to have an abortion.
  • Doc chases Meredith into the bathroom. She sits down to eat pizza with George and Izzie.

Notes and Trivia[]

  • This episode's title originated from Begin the Begin originally sung by R.E.M.
  • This episode scored 18.97 million viewers.
  • This episode marks the first appearance of Jeffrey Dean Morgan as Denny Duquette, Jr.


Meredith: Such a good dog! Who's Mommy's good boy? (turns and looks at Izzie and George) C'mon, what are you doing, we're gonna be late.
George: Uh— We need to talk about the dog.
Izzie: That's not a dog, it's a hyena that escaped from the zoo, dressed in dog clothing.
George: Whatever. I don't chew up his clothes. I don't urinate on his bed. I don't try to mount him from behind.
Meredith: People, he's our dog. We love our dog. He loves us.
Izzie: Mount you from behind?
George: He tries to.

See Also[]

A complete overview of this episode's crew can be found here.

The Grey Matter blog post on this episode can be found here.

Begin the Begin