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Grey's Anatomy Universe Wiki
Grey's Anatomy Seasons
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The show was officially renewed for a twenty-first season on April 2, 2024 for the 2024-25 broadcast season. It premiered on September 26, 2024 and aired on Thursday at 10/9c PM. The season consists of 18 episodes.

Summary[]

Plots[]

  • Meredith and Catherine keep arguing about the Alzheimer's research, and Meredith prepares for an inevitable legal battle against her until she discovers that Catherine's cancer is progressing. Meredith is forced to treat her and hide the news from Richard.
  • Jules and Mika begin dating, but when Mika discovers that her sister Chloe has cancer, she ditches Jules to support her. However, when they are in a car accident, Chloe dies, leading Mika to decide to leave the hospital, leaving Jules heartbroken.
  • Jo deals with her frustrations and fears upon discovering she is pregnant with twins, which strains her relationship with Link.
  • Kwan attempts to restart his relationship with his amnesiac ex-fiancée, Molly Tran. However, Molly decides to undergo experimental surgery to try to recover her lost memories. When it fails, Kwan realizes she is only clinging to him out of desperation.
  • Levi begins dating James Morgan and is offered a research position in Texas, which he decides to accept.
  • Jo and Lucas get in the middle of a robbery at a convenience store.
  • Lucas asks Catherine to reconsider his remediation.
  • Lucas and Simone's relationship begins to fracture due constant disagreements and Simone's fear of going too fast.
  • Ben returns to the hospital as a probationary resident, but struggles to adjust and follow the rules, causing conflict with Teddy and Bailey.
  • Teddy and Owen decide to open their marriage.
  • Link and Jo get married.
  • Jules asks Winston to be her mentor and the two of them work wonderfully together until he starts developing feelings for her and pushes her away.
  • A patient's worried mother holds Amelia, Simone, and Lucas hostage and forces them to operate on her daughter. This leads to an explosion when they learn the gas tank she used had filled the room with gas.

Cast[]

Main Cast[]

Recurring Guest Stars[]

Recurring Co-Stars[]

Notes and Trivia[]

  • The show was officially renewed for season 21 on April 2, 2024.[1]
  • On May 13, 2024, it was announced that Jake Borelli would be leaving the series after season 20 with negotiations taking place for him to return for season 21 for a few episodes to wrap up Levi's storyline.[2]
  • On May 15, 2024, it was announced that Midori Francis is leaving the series as well, with negotiations taking place for her to return for a few episodes in season 21 to wrap up Mika's storyline.[3]
  • Furthermore, it was announced that as part of a cost-cutting move, several of the veteran series regular would face a reduction of their episodic guarantee (the number of episodic fees per season each series regular is entitled to per their contract), likely resulting in less appearances by said regulars throughout the season.[2]
  • Meredith narrates all of the voiceovers this season, just like happened in season one, eighteen and twenty.
  • Filming for the season presumably started on July 24, 2024. James Pickens, Jr. and Anthony Hill filmed together that day, as did Camilla Luddington and Chris Carmack. Jake Borelli shot his first scenes for the season that day as well, although other actors may have shot scenes on the days prior.[4][5][6]
  • Filming for the season wrapped on March 27, 2025, twenty years to the day after the first episode premiered.[7]
  • On August 19, 2024, they were filming I Can See Clearly Now.[8]
  • The table read for This One's for the Girls took place on August 20, 2024.[9]
  • On January 9, 2025, production shut down due to the L.A. wildfires. It resumed on January 14.[10]
  • This is the first season since her introduction in Season 10 that does not feature Kelly McCreary as Maggie Pierce.

Episodes[]

No. in series No. in season Title[11] Directed by Written by Original air date[11]
431 1 "If Walls Could Talk" Debbie Allen Meg Marinis September 26, 2024
After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.
432 2 "Take Me to Church" Kevin McKidd Michelle Lirtzman October 3, 2024
Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.
433 3 "I Can See Clearly Now" Victoria Mahoney Mark Driscoll October 10, 2024
Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben's interview doesn't go as planned. Meredith's secret causes tension with Richard.
434 4 "This One's for the Girls" Debbie Allen Briana Belser October 17, 2024
Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.
435 5 "You Make My Heart Explode" Vanessa Parise Zoanne Clack October 24, 2024
During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.
436 6 "Night Moves" Bille Woodruff Jase Miles-Perez November 7, 2024
Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.
437 7 "If You Leave" Allison Liddi-Brown Tameson Duffy November 14, 2024
The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.
438 8 "Drop It Like It's Hot" Kevin McKidd Jess Righthand November 21, 2024
In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.
439 9 "Hit the Floor" Linda Klein Jamie Denbo March 6, 2025
The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.
440 10 "Jump (for My Love)" Jesse Williams Julie Wong March 13, 2025
Meredith and Nick return to Grey Sloan to treat a liver transplant patient. Meanwhile, Bailey hosts an intern retreat at her home, and Winston and Ben aid an unexpected crash victim.
441 11 "I Still Haven't Found What I'm Looking For" Allison Liddi-Brown Carol Brown March 20, 2025
Following a difficult case, the team faces the complexities of medical ethics. Meanwhile, Bailey continues to navigate her working relationship with Ben, while a group of college students on a scavenger hunt causes chaos around the hospital.
442 12 "Ridin' Solo" Kevin McKidd Sandra Hamada March 27, 2025
Meredith and Amelia prepare a funding proposal for their Alzheimer's research. Meanwhile, Teddy and Owen hit a breaking point in their marriage, while Jules has an awkward encounter with Dr. Beltran.
443 13 "Don't You (Forget About Me)" Kim Raver Julie Wong & Michelle Lirtzman April 3, 2025
Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery. Teddy and Bailey attend a medical conference and run into Dr. Cass Beckman. Meanwhile, Jo struggles with her irritation toward a younger OB-GYN.
444 14 "Love in the Ice Age" Morenike Joela Evans Kingsley Ume April 10, 2025
Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case. Meanwhile, Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.
445 15 "Bust Your Windows" Lisa Leone Scott Brown April 17, 2025
A window washer's platform crashes through a hospital window, testing the Grey Sloan team's limits. Meanwhile, Blue and Simone clash over their living arrangements, and Lucas strives to impress Catherine while on her service.
446 16 "Papa Was a Rollin' Stone" Chandra Wilson Jess Righthand May 1, 2025
Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.
447 17 "Love You Like a Love Song" Kevin McKidd Julie Wong & Michelle Lirtzman May 8, 2025
Jo and Link's wedding day arrives, along with some visitors. Meanwhile, Teddy and Owen are met with a familiar face seeking treatment, and Lucas disagrees with Simone on how to approach a patient's worsened condition.
448 18 "How Do I Live" Debbie Allen Meg Marinis May 15, 2025
While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.

Reception[]

Gallery[]

Cast Promotional Photos[]

Posters[]

Ellen Pompeo Hollywood Walk of Fame Star[]

Trailers[]


References[]