Grey's Anatomy Seasons
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The sixth season of Grey's Anatomy premiered September 24, 2009 and ended May 20, 2010. It was broadcast on Thursday nights at 9 PM on ABC. The season consists of 24 episodes, both starting and ending with two-part episodes.


Expect more competition, more doctors, and much more drama as Seattle Grace merges with a competing hospital. Meredith, Derek, Izzie, and the rest of the doctors face a brand new challenge with the arrival of doctors from Mercy West. Battle lines are drawn and rivalries reach new heights in an unforgettable year at Seattle Grace.



Main CastEdit

Special Guest StarEdit

Recurring Guest StarsEdit

Prominent Guest StarsEdit

Recurring Co-StarsEdit

Notes and TriviaEdit

  • During early season six, Ellen Pompeo was pregnant and showing, so most shots of her are above the chest or her belly is covered with something.
    • She was given four weeks off and the writers allowed her to return for only short times in the following weeks.
  • It is the first season to not feature T.R. Knight as George O'Malley and Goodbye marks the first episode to not feature him.
  • This is the last season to feature Katherine Heigl as Izzie Stevens, also marking several episodes without Izzie. She remained credited for those episodes until she was released from her contract and thereby got removed from the credits.
    • Izzie being fired in Invasion and her absence in the consequent three episodes was to give Katherine room on her schedule to film the comedy movie Life As We Know It. She briefly returned for one episode, only to be absent again for two episodes.
    • She returned for I Like You So Much Better When You're Naked, which was supposed to be her final episode before her maternity leave. However, while she was scheduled to return for the last five episodes of the season, Katherine didn't return to the set as she was released from her contract per her request. 
  • This season has the highest number of episodes that are not narrated solely by Meredith, with 6. This record is shared with season ten. In this season, it may also be a result of Ellen Pompeo's pregnancy.
  • Jessica Capshaw was promoted to series regular after previously recurring.



DVD ReleaseEdit


The "Grey's Anatomy: Complete Sixth Season – More is Better" boxset was released in region 1 on September 14, 2010. On December 5, 2011 and November 3, 2010, the DVD was released in regions 2 and 4 respectively.

Set DetailsEdit

The boxset contains the 24 episodes of the season, with one extended. The DVD box contains 6 discs. Other set details are:

  • English (Dolby Digital 5.1 Surround)
  • Audio Commentaries

Special FeaturesEdit

Additional to the episodes, the season 6 DVD set also contains a couple of special features:


Cast Promotional PhotosEdit